Principal Investigator/Program Director (Last, First, Middle):

Gruber, Andras

 

BIOGRAPHICAL SKETCH

Provide the following information for the key personnel in the order listed on Form Page 2.
Follow this format for each person.  DO NOT EXCEED FOUR PAGES.

 

NAME

Andras Gruber, M.D.

POSITION TITLE

Associate Professor of Biomedical Engineering

 

EDUCATION/TRAINING  (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)

INSTITUTION AND LOCATION

DEGREE

(if applicable)

YEAR(s)

FIELD OF STUDY

Semmelweis Medical Univ., Budapest, HU

 

MD

1979

Medicine

Postgraduate Medical School, Budapest, HU

 

Board Cert. Cert.

1984

Internal Medicine

The Scripps Research Institute, La Jolla, CA

-

1986-89

Postdoc, biochem.

 

 

 

 

 

 

 

 

 

A. Positions and Honors

Positions and Employment

1979-1985    Medical residency, and staff physician, Internal Medicine, Postgraduate Med. School, Budapest, HU

1985-1986    Staff physician, Internal Medicine, Szonyi T. County Hospital, Vac, HU 

1986-1989    Postdoctoral Research Fellow, The Scripps Research Institute, La Jolla, CA

1989-1991    Research Associate, The Scripps Research Institute, La Jolla, CA

1991-1992    Senior Research Associate, The Scripps Research Institute, La Jolla, CA

1992-1994    Assistant Member, The Scripps Research Institute, La Jolla, CA

1994-1998    Director, Medical Affairs, Depotech Corporation, San Diego, CA

1994- pres    Adjunct Assistant Professor, The Scripps Research Institute, La Jolla, CA

1998-1999    Chief Scientific and Medical Officer, Head of R&D, Pharmanetics, Inc., Raleigh, NC

2000- 2003   Research Professor, GeorgiaTech/Emory University School of Medicine, Atlanta, GA

2004- pres    Associate Professor, Oregon Health and Science University (OHSU), Portland, OR

Professional Memberships

1987-               International Society of Thrombosis and Hemostasis, Member

1995-              American Academy of Pharmaceutical Physicians, Member

2002-              American Society of Hematology, Member

Honors

1989 Protein C and tPA or urokinase in a primate thrombosis model. American Heart Association, California Affiliate Research Fellowship, San Diego, California

1991 Activated protein C in smokers' thrombosis. Tobacco-Related Disease Research Program, State of California, University of California, San Diego, California, Research Grant (PI)

1994 Mechanism of Ischemic Stroke. DHHS, Public Health Service, (NIH), University of Southern California Program Project Research Grant (Co-investigator)

2003  Anticoagulant thrombins in vitro and in vivo.  NIH R01 Washington University (Co-investigator)

 

B. Selected peer-reviewed publications (in chronological order)

1. Gruber A, Blasko Gy, Sas G: Functional deficiency of protein C and skin necrosis in multiple myeloma. Thromb Res 42:579-82, 1986.

2. Gruber A, Griffin JH, Harker LA, Hanson SR: Inhibition of platelet-dependent thrombus formation by human activated protein C in a primate model. Blood 73:639-42, 1989.

3. Gruber A, Hanson SR, Kelly AB, Yan BS, Bang N, Griffin JH, Harker LA: Inhibition of thrombus formation by activated recombinant protein C in a primate model of arterial thrombosis. Circulation 82:578-85, 1990.

4. Espana F, Gruber A, Heeb MJ, Hanson SR, Harker LA, Griffin JH: In vivo and in vitro complexes of activated protein C with two inhibitors in baboon. Blood 77:1754-1760, 1991.

5. Heeb MJ, Gruber A, Griffin JH: Identification of divalent metal ion-dependent inhibition of activated protein C by "a2-macroglobulin and "a2-antiplasmin in blood and comparisons to inhibition of factor Xa, thrombin and plasmin. J Biol Chem 266:17606-12, 1991

6. Gruber A, Harker LA, Hanson SR, Kelly AB, Griffin JH: Antithrombotic effects of combining activated protein C with urokinase in non-human primates. Circulation 84:2454-2462, 1991 (with editorial)

7. Gruber A, Griffin JH: Direct detection of activated protein C in blood from human subjects. Blood 79:2340-8, 1992.

8. Griffin JH, Gruber A, Fernandez JA: Reevaluation of total, free and bound protein S and C4b-binding protein levels in plasma anticoagulated with citrate or hirudin. Blood 79:3203-11, 1992.

9. Conard J, Bauer KA, Gruber A, Griffin JH, Schwarz HP, Horellou MH, Samama MM, Rosenberg RD: Normalization of markers of coagulation activation with a purified protein C concentrate in adults with homozygous protein C deficiency. Blood 82:1159-64, 1993.

10. Hanson SR, Griffin JH, Harker LA, Kelly AB, Esmon CT, Gruber A: Antithrombotic effects of thrombin-induced activation of endogenous protein C. J Clin Invest 92:2003-12; 1993

11. Gruber A, Pal A, Kiss RG, Sas G, Griffin JH. Generation of activated protein C during thrombolysis. Lancet 342:1275-6, 1993.

12. Gruber A, Mori E, Heeb MJ, Zoppo GD, Chang CM, Griffin JH: Alteration of fibrin network by activated protein C. Blood 83:2541-8, 1994.

13. Granger CB.  Miller JM.  Bovill EG.  Gruber A.  Tracy RP.  Krucoff MW. Green C.  Berrios E.  Harrington RA.  Ohman EM. Califf RM. Rebound increase in thrombin generation and activity after cessation of intravenous heparin in patients with acute coronary syndromes. Circulation 91:1929-35, 1995.

14. Fisher M, Fernandez JA, Ameriso SF, Xie D, Gruber A, Paganini-Hill A, Griffin JH. Activated protein C resistance in ischemic stroke not due to factor V arginine506->glutamine mutation. Stroke 27:1163-6, 1996.

15. Macko RF, Ameriso SF, Gruber A, Griffin JH, Fernandez JA, Barndt R, Quismorio FP, Weiner J, Fisher M. Impairment of the protein C system and fibrinolysis in infection-associated stroke. Stroke 27:2005-11, 1996.

16. Kim T, Murdande S, Gruber A, Kim S. Sustained-release morphine for epidural analgesia in rats. Anesthesiology 85:331-8, 1996

17. Petaja J, Fernandez JA, Gruber A, Griffin JH. Anticoagulant synergism of heparin and activated protein C in vitro. Role of a novel anticoagulant mechanism of heparin, enhancement of inactivation of factor V by activated protein C. J Clin. Invest 99:2655-63, 1997.

18. Fernandez JA, Petaja J, Gruber A, Griffin JH. Activated protein C correlates inversely with thrombin levels in resting healthy individuals. Am J Hematol 56:29-31, 1997.

19. Macko RF, Killewich LA, Fernandez JA, Cox DK, Gruber A, Griffin JH. Brain-specific protein C activation during carotid artery occlusion in humans. Stroke 30:542-5, 1999.

20. Gruber A. Coagulation at the point of care. Advance Admin Lab 9:38-42, 2000 (Review)

21. Gruber A, Cantwell AM, Di Cera E, Hanson SR. The Thrombin Mutant W215A/E217A Shows Safe and Potent Anticoagulant and Antithrombotic Effects in Vivo. J Biol Chem. 277:27581-4, 2002

22. Fernandez JA, Gruber A, Heeb MJ, Griffin JH. Protein C pathway impairment in asymptomatic cigarette smokers. Blood Cells, Molecules, and Diseases 29:73-82, 2002

23. Gruber A, Hanson SR. Factor XI-dependence of surface- and tissue factor-initiated thrombus propagation in primates. Blood 102:953-5, 2003

24. Gruber A, Hanson SR. Potential new targets for antithrombotic therapy. Curr Pharm Des 9:2367-74, 2003 (Review)